Hyaluronidase Liporase

Liporase Product Information

Ingredients:

• Hyaluronidase: 1500 IU per vial
• Excipients: Sufficient to make up one vial

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Indications and Uses of Liporase

Uses:

• Hyaluronidase is an enzyme that temporarily hydrolyzes hyaluronic acid polysaccharide found in connective tissues, effectively dissolving fillers by breaking down their bonds in the skin.
• Increases the permeability of subcutaneous fluids.
• Enhances fluid reabsorption and reduces edema caused by fluid retention in the skin.
• In case of overdose, Hyaluronidase helps to dissolve excess substances, mitigating edema and balancing metabolism.
• Facilitates the diffusion of solutions to treatment areas, enhancing efficacy.
• Aids in fat reduction in LLD therapy.

Instructions for Use:

• Used in conjunction with other infusions to enhance permeability and deliver medication to treatment areas.
• Reduces edema due to fluid retention in the skin: increases fluid reabsorption, dissolves excess substances, and alleviates swelling.
• Used for LLD therapy to assist in fat reduction.
• Administered via intramuscular or subcutaneous injection.
• Dosage: For subcutaneous administration, dissolve 1500 IU of hyaluronidase in 1 ml of diluent (sterile water or saline) and inject at the site prior to infusion or into the infusion set about 2 cm from the needle. This dosage is effective for approximately 500-1000 ml of most fluids. For subcutaneous or intramuscular injection, dissolve directly in the solution to be injected.

  In cases of hematoma, dissolve 1500 IU in 1 ml of sterile water or saline and inject into the hematoma area. For vascular extravasation, mix 1500 IU of hyaluronidase with 1 ml of sterile water or 0.9% saline, then inject into the extravasation site as soon as it’s detected.

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Contraindications of Liporase

• Hypersensitivity to hyaluronidase.
• Not to be used intravenously.
• Not to be used for swelling due to insect bites or animal bites, or at sites of infection.
• Not to be used in anesthesia procedures during unexplained early labor.

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Precautions When Using Liporase

• Check the color of the product before dilution; discard if discoloration occurs.
• After dilution, ensure the solution is clear, free of floating particles.
• Administer immediately after dilution to avoid contamination.
• Preparation and administration must be performed by qualified personnel.
• Discard any unused product; do not store for future use.
• Monitor fluid volume and infusion rate for children and elderly patients, especially those with renal impairment, to avoid fluid overload.

Use in Pregnant or Breastfeeding Women:

• No evidence of safety for use during pregnancy and breastfeeding; weigh benefits to the mother against risks to the baby before use and only use if absolutely necessary with no alternatives.

Driving and Operating Machinery:

• No studies on the effects on driving or operating machinery have been conducted.

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Side Effects of Liporase

• Edema: reported in connection with hypodermoclysis. Allergic reactions with local anesthetics in ophthalmology may cause abdominal swelling.
• Severe allergic reactions: anaphylactic shock.
• Local allergies, infections, bruising, bleeding.

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Drug Interactions

• Some incompatibilities may occur:
  • Physical incompatibilities: heparin, adrenaline.
  • Chemical incompatibilities: furosemide, benzodiazepines, and phenytoin.

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Storage

• Store in a dry, cool place, protected from direct light, below 25°C.
• Keep out of reach of children.